Nope, not so far. I’ve worn them all my life and am very used to them. I work at my computer a lot though, and it is important for everyone (not just glasses wearers) to take regular breaks from looking at screens. Which I try to do. I usually go for a quick walk around the building I work in.
My glasses don’t really get in the way of anything- I rock climb and play lots of sports with them on and haven’t had any problems. I guess if I started playing rugby that might be more of an issue!